Sunday, October 30, 2016

Welcome Reception and Keynote Speech at the Boston Cambridge Marriott

50 Broadway, Cambridge, MA 02142; 5:00-9:00 PM

Monday, October 31, 2016

Workshop at the Broad Institute 
7 Cambridge Center
Cambridge, MA 02142

Driving Directions 


Elizabeth Brooks 
Mass General Cancer Center 

Workshop on Splicing Factor Mutations in Cancer 

Program Overview

The discovery of recurrent mutations in core components of the RNA splicing complex (the “spliceosome”) in diverse cancers has opened a new avenue of research in cancer biology and therapeutics. These mutations are particularly prevalent in human myelodysplastic syndromes (MDS) and chronic lymphocytic leukemia (CLL), but are also present in solid tumors, including non-small cell lung cancer and uveal melanoma. A growing literature has described the clinical correlates of these mutations, their impact on splicing, and their functional consequences in model organisms. Significant gaps remain in our understanding of the biology of spliceosome-mutant cancers and their potential vulnerability to targeted and novel therapies.

This workshop is designed to communicate knowledge and facilitate new and existing collaborations through oral sessions, poster presentations, and informal discussions. An interdisciplinary group of participants will be in attendance, drawing from backgrounds in fundamental mechanisms of splicing, genetics of human cancer, animal models of human cancer, and experimental therapeutics.

Confirmed speakers:

  • Michael Green (University of Massachusetts)
  • Omar Abdel-Wahab (Memorial Sloan Kettering Cancer Center)
  • Dan Larson (NIH)
  • Ben Ebert (Harvard Medical School)
  • William Fairbrother (Brown University)
  • Robert Bradley (University of Washington)
  • Peter Smith (H3 Biosciences)
  • Thomas Webb (SRI)

Abstract Submission Instructions

Each abstract should be submitted as a separate word document attachment to Please use the following format:

Title.  Provide a brief, descriptive abstract title.

Authors.  List all contributing authors with affiliations.

Text.  The abstract may be structured (i.e., divided into sections using terms such as Introduction, Methods, Results, Conclusions, etc.) or unstructured.  Do not exceed 3,800 characters (excluding spaces).  A single figure or table may be included. 

Abstracts will be printed in the program book distributed to all registered participants. Therefore, authors should exercise caution when including confidential information. SUBMISSION DEADLINE EXTENDED: September 26, 2016.

We have reserved a block of rooms at the Boston Cambridge Marriott for the nights of October 30 and 31 at a rate of $279/night. Please note that space is limited and rooms MUST be booked no later than Sunday, October 9, 2016. Please mention the name and date of the program when calling to book your room (617-494-6600) or click here to book your room online.

Meeting Locations
Sunday, October 30
Welcome Reception and Keynote Speech will take place at the Boston Cambridge Marriott. Registration and cocktail hour will be from 5:00-6:00 PM followed by the Keynote Speech and dinner.

Monday, October 31
The "Workshop on Splicing Factor Mutations in Cancer" will take place in the Main Auditorium in the lobby of the Broad Institute. 

Marriott to Broad Institute
The Broad Institute is located one block away from the Marriott. Exit the back of the Marriott onto Main Street and walk one block to your right. You will pass the Broad Institute on your right to enter at the Main Entrance doors. (There are two buildings to the Broad, the event is held in the building facing Main Street, NOT Ames Street.)

Public Transportation
Both the Marriott and Broad are conveniently located by the "Kendall/MIT" RED line stop on the T.

Please visit this website for the nearest parking locations and rates:

Driving Directions
For more information on directions to the Marriott, please visit: