Date:  Wednesday, November 6,  2019
Time:  11:30 AM to 2:30 PM EST

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North Carolina State - BTEC, NC

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Carol Stanton 
Eppendorf North America 


Complimentary Bioprocess Workshop
North Carolina State - BTEC

Register Now!

Please plan to join us for lunch.

Eppendorf invites you to be our guest at a complimentary bioprocess workshop where attendees will benefit as we present and discuss information on Implementation of an Affordable and Scalable Manufacturing Strategy for Gene Therapy as well as A Beginner’s Guide to Bioprocess Modes – Batch, Fed-Batch, and Continuous Processing. You will also learn about scalable processes using Raman-based control strategies presented by Kaiser.

Eppendorf's integrated portfolio of bioprocess systems, software and consumables will be on hand for demonstration including the DASbox® Mini Bioreactor System, the BioFlo® 120 and BioFlo® 320 Controllers, as well as our full line of Single-use Vessels.

The Eppendorf bioprocess solutions have been successfully used in the biopharmaceutical, chemical and nutrition industries as well as applied research for decades.  Our strong synergies in bioreactor technology and polymer manufacturing have helped Eppendorf emerge as a global player and a valuable resource to our customers.


Implementation of an Affordable and Scalable Manufacturing Strategy for Gene Therapy
Upstream bioprocess development is an integral part of gene therapy product development. Cell culture bioprocess development is usually carried out at small working volumes. This helps save time and resources, because several experiments can be conducted in parallel, costs for media are kept low, and relatively little laboratory space is required. When more material is needed for characterization, trial runs, and finally for commercialization, biopharmaceutical companies transition the process to bench scale and then up to pilot or production scale. In this presentation, we will present bioprocess solutions for parallel process development at small scale. Furthermore, we will discuss bioreactor scalability and address several scaling approaches.

A Beginner’s Guide to Bioprocess Modes – Batch, Fed-Batch, and Continuous Processing
We will discuss the differences between batch, fed-batch, and continuous fermentation and how these influence culture growth. As an example, we look at E. coli fermentation processes at bench scale. We track the biomass and nutrient concentrations during batch, fed-batch, and continuous fermentation runs. We explain different methods to analyze the process, including determination of biomass, growth rate, productivity, yield, and analysis of process costs. The  comparisons can help bioprocess engineers to select the most appropriate method to meet their needs.  In our examples we studied E. coli fermentation at bench scale. The principles may also apply to bioprocesses using other microbes or mammalian cells, at both smaller and larger scales.

Develop Robust, Scaleable and Transferable Processes More Quickly with Kaiser Raman
Implementing Kaiser Raman during process development enables adoption of QbD principles to define manufacturing design spaces, optimize process conditions, and demonstrate process robustness and quality, while also providing improvements to product quality and yield through Raman-based control strategies. Raman is currently being employed to maximize downstream efficiency and provide improved downstream characterization. Kaiser Raman is also well equipped to meet the ever-increasing market demand for easy to use and reliable single use technology, even at the smallest scales. Current market case studies will be presented.

Lunch will be served.

Register Now!

Please plan to join us for lunch.

For more information please contact Carol Stanton at (508) 740-8055 or email her at stanton.c@eppendorf.com.

Participation is free but space is limited so please be sure to click on the "Register Now!" button to register for the event and reserve your spot.  We look forward to seeing you!