GHUCCTS LogoCSD LogoCenter for the Study of
Sex Differences in Health,
Aging and Disease

Contact:

Kathryn Sandberg 
Georgetown University 
 
sandberg@georgetown.edu 

When

Wednesday October 6, 2010 at 4:00 PM EDT
-to-
Friday October 8, 2010 at 12:00 PM EDT


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Where

New Research Building Auditorium               Georgetown University
Entrance 3
4000 Reservoir Road, NW
Washington, DC 20057
 

 
Driving Directions 

Navigating the Road to Personalized Medicine: Scientific, Ethical and Public Policy Issues

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WORKSHOP OBJECTIVE:  The goal of this workshop is to define the clinical, scientific, ethical and public policy issues surrounding the development of race-based therapeutics.  The increasing diversity of the United States population presents major challenges for the medical and healthcare communities, while the rapid evolution of knowledge on the impact of race in health and healthcare offers enormous potential for providing individualized medical care. There are, however, significant gaps in our knowledge on the role of race in human biology and health. Furthermore, there is a need to improve the translation of basic research to clinical treatment in racially and ethnically diverse populations and to engage underserved populations in health and medical research to enable the development of improved treatments in these populations. The goal of this conference is to bridge the current gaps of knowledge in a focused and interdisciplinary approach by having basic scientists, clinical researchers, bioethicists and public policy experts participate. By convening an interdisciplinary workshop that focuses on the current state of clinical research regarding the impact of race on health and disease, the limitations of current knowledge and the ethical and public policy implications of this research, this workshop will advance the global mission to eliminate health and healthcare disparities.

DAY 1

 Wednesday October 6, 2010

3:00 – 5:00 pm

Registration

4:00 – 4:05 pm

Welcome

Kathryn Sandberg, PhD, Chair
Professor, Division of Nephrology and Hypertension, Department of Medicine and Director, Center for the Study of Sex Differences in Health, Aging and Disease, Georgetown University, Washington, DC

4:05 – 4:15 pm

Health Disparities in Biomedical Research                                  John Ruffin, PhD
Director, National Center on Minority Health and Health Disparities, National Institutes of Health, Bethesda, MD

Session I

Science and Public Policy and the Development of Race-based Therapeutics

4:15 – 4:20 pm

Anne E. Sumner, MD, Co-Chair
Senior Clinical Investigator, National Institutes of Diabetes, Digestive Disorders and the Kidney, National Institutes of Health, Bethesda, MD; Professor, Division of Endocrinology and Metabolism, Department of Medicine, Georgetown University, Washington, DC

4:20 – 5:10 pm

Race-based therapeutics: Story begins with BiDil                    Robert Temple, MD
Center for Drug Evaluation and Research, Deputy Director for Clinical Science and Director, Office of Drug Evaluation 1, Food and Drug Administration, Washington, DC

5:10 – 5:15 pm

Joseph G. Verbalis, MD, Co-Chair
Professor and Chief, Division of Endocrinology and Metabolism, Department of Medicine and Co-Director, Georgetown-Howard Universities Center for Clinical and Translational Science, Georgetown University, Washington, DC

5:15 – 6:05 pm

Contributions of systems medicine to the study of race and ethnicity                                                                                       Howard Federoff, MD, PhD
Executive Vice President for Health Sciences and Executive Dean of the School of Medicine, Georgetown University, Washington, DC

6:05 – 7:30 pm

Reception

7:30 – 9:30 pm

Working dinner (Speakers, Moderators and Discussants)

DAY 2

 Thursday October 7, 2010

7:30 ­– 2:30 pm

7:30 – 9:30 am

Registration

Breakfast (provided for all attendees)

Session II

Intersection of Race, Obesity and Heart Disease

8:30 – 8:35 am

Barbara V. Howard, PhD, Moderator
Professor, Department of Medicine, Georgetown University, Washington, DC; Senior Scientist and Former President of MedStar Health Research Institute, Washington, DC

8:35 – 9:05 am

The genetics of race and disease: how important is race?    Charles N. Rotimi, MD
Director, NIH Intramural Center for Genomics and Health Disparities, Bethesda, MD

9:05 – 9:35 am

Heart disease in black and white: risk and race                          Anne E. Sumner, MD
Senior Clinical Investigator, National Institutes of Diabetes, Digestive Disorders and the Kidney, National Institutes of Health, Bethesda, MD; Professor, Division of Endocrinology and Metabolism, Department of Medicine, Georgetown University, Washington, DC

9:35 – 10:05 am

Revealing racial differences in cardiac risk and cardiac care      Kim A. Williams, MD
Dorothy Susan Timmis Professor and Chair, Division of Cardiology, Department of Medicine, Wayne State University School of Medicine, Harper University Hospital, Detroit, MI 

10:05 – 10:15 am

Discussion

Daniel F. Sarpong, PhD, Discussant                                      Associate Director, Data Management, IT & Quality Assurance,  Jackson Heart Study, Jackson State University, Jackson, MI

Jason G. Umans, MD, PhD, Discussant                                Associate Professor, Departments of Medicine and Obstetrics and Gynecology, Georgetown University, Washington, DC; Scientific Director, Penn Medical Laboratory, MedStar Health Research Institute, Washington, DC

10:15 – 10:30 am

Coffee Break

Session III

Race and Diverse Disease Manifestations

10:30 – 10:35 am

Joseph J. Jacobs, MD, MBA, Moderator
Associate Medical Director, Abbott Molecular, Des Plaines, IL

10:35 – 11:05 am

Breast cancer incidence rates in young 'Black' and 'White' women in the US: What evidence is there for the genetic hypothesis?
Ellen Velie, MPH, PhD                                                              Associate Professor, Department of Epidemiology, Michigan State University, East Lansing, MI

11:05 – 11:35 pm

What have the LUMINA and CLEAR studies revealed about race and autoimmune disease?                                                        Graciela S. Alarcón, MD, MPH
Jane Knight Lowe Chair of Medicine in Rheumatology, Department of Medicine, Division of Clinical Immunology and Rheumatology, University of Alabama, Birmingham, AL

11:35 – 11:45 pm

Discussion

11:45 – 1:15 am

Lunch (provided for all attendees)

Session IV

Ethics of Race-Based Therapeutics

1:15 – 1:20 pm

Madison Powers, PhD, Moderator
Director and Senior Research Scholar, Kennedy Institute of Ethics and Professor, Department of Philosophy, Georgetown University, Washington, DC

1:20 – 1:50 pm

The dilemma of "difference": historical and ethical issues surrounding race-based therapeutics                                     Vanessa Northington Gamble, MD, PhD
University Professor of Medical Humanities and Professor of Health Policy and American Studies, George Washington University, Washington, DC

1:50 – 2:20 pm

Race-based therapeutics and the Law                                              M. Gregg Bloche, JD, MD
Professor, School of Law and Co-Director, Georgetown-Johns Hopkins Joint Program in Law and Public Health, Georgetown University, Washington, DC

2:20 –  2:30 pm

Discussion

Leslie R. Hinkson, PhD, Discussant                                       Assistant Professor, Department of Sociology, Georgetown University, Washington, DC

2:30 – 2:45 pm

Coffee Break

Session V

A Translational Science View of Race

2:45 – 2:50 pm

Jason G. Umans, MD, PhD, Moderator
Associate Professor, Departments of Medicine and Obstetrics and Gynecology, Georgetown University, Washington, DC; Scientific Director, Penn Medical Laboratory, MedStar Health Research Institute, Washington, DC

2:50 – 3:20 pm

Race and animal models: benefits and challenges                 Kathryn Sandberg, PhD
Professor, Division of Nephrology and Hypertension, Department of Medicine and Director, Center for the Study of Sex Differences in Health, Aging and Disease, Georgetown University, Washington, DC

3:20 – 4:10 pm

Race-based therapeutics from a drug discovery angle             Milton Brown, MD, PhD
Director, Drug Discovery Program and Edwin H. Richard and Elisabeth Richard von Matsch Endowed Chair in Experimental Therapeutics, Georgetown University, Washington, DC

4:10 – 4:20 pm

Discussion

Jason G. Umans, MD, PhD, Discussant                                Associate Professor, Departments of Medicine and Obstetrics and Gynecology, Georgetown University, Washington, DC; Scientific Director, Penn Medical Laboratory, MedStar Health Research Institute, Washington, DC

Session VI

Working Group: Drafting of Recommendations

4:20 – 6:30 pm

Building Consensus Statement: All Participants Welcome

6:30 – 7:00 pm

Break

7:30 – 9:30 pm

Working dinner 

DAY 3

 Friday October 8, 2010

7:30 – 9:30 am

Breakfast (provided for all attendees)


Session VII

Drafting of Recommendations

8:30 – 11:00 am

Building Consensus Statement: All Participants Welcome

11:00 – 11:30 am

Working Group Presentations

11:30 – noon

Closing Remarks

Vivian W. Pinn, MD                                                                         Associate Director for Research on Women's Health and Director, Office of Research on Women's Health, National Institutes of Health, Bethesda, MD

Joseph G. Verbalis, MD                                                            Professor and Chief, Division of Endocrinology and Metabolism, Department of Medicine and Co-Director, Georgetown-Howard Universities Center for Clinical and Translational Science, Georgetown University, Washington, DC