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"Techniques for 3-dimensional lineage tracing during tumorigeneses"

Dr. Snyder leads the Cancer Initiation and Cancer Cell Behavior lab at Duke University. Their research mission is to unravelthe mysteries of how cancer cells adapt and thrive in the crucial pre-diagnosis phase. Additionally, Dr. Snyder's lab plays apivotal role in the Center for Applied Therapeutics, where their cutting-edge models are shared as invaluable tools forpreclinical and translational research.

At the heart of their work lies a profound fascination with the earliest stages of tumorigenesis, where cancer cells and theirintricate ecosystems adapt to give rise to aggressive, metastatic cancers. Leveraging innovative cancerrainbow models(Crainbow) and hyperspectral techniques, Dr. Snyder's lab explores tumor initiation with unprecedented spatial and temporalresolution. Their interdisciplinary approach spans systems biology, single-cell analyses, and genetic engineering, making fora dynamic and far-reaching research agenda.

In this webinar, Dr. Snyder will:

• Discuss the use of cancerrainbow mice for tracing genetic heterogeneity during tumorigenesis.
• Explore the intricacies of imaging and tissue processing for 3D lineage tracing.