Friday, June 29, 2018 at 8:30 AM EDT
Saturday, June 30, 2018 at 12:00 PM EDT

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Simches Research Center, 3rd Floor 
Charles River Plaza
185 Cambridge Street
Boston, MA 02114

Driving Directions 


Elizabeth Brooks 
Mass General Cancer Center 


Wyndham Boston Beacon Hill
$239 for the dates of June 28-30, 2018. 
For reservations, please click HERE or call (877) 999-3223 and refer to the “MGH Brain Metastases (METs) Symposium" Room Block and/or ID #: 0628MGHCCB.

All reservations MUST be in place by May 15, 2018.

***For assistance or if you require additional information, please call the hotel directly at 617-742-7630. 

The Liberty Hotel
for the dates of June 28-30, 2018. To book, click here: MGH Brain METs Symposium, OR call hotel directly: 866-961-3778 and mention "MGH Brain METs Symposium June 2018".

This is a LIMITED room block. Reservations must be in place by 5:00 pm on Tuesday, May 29, 2018.


Brain Metastasis Research:
From Basic Science to Clinic 

A free symposium, hosted by:
Mass General Cancer Center


Brain metastases are a common and devastating clinical complication of cancer. Approximately 25% of patients with cancer will develop brain metastases. Median survival is limited after the diagnosis of a metastasis in the central nervous system despite having received standard therapies. Historically, our limited understanding of the molecular drivers and the microenvironment of brain metastases has hampered the application and development of novel therapeutics for this common complication of cancer. Recently, significant progress has been made in our understanding of the mechanisms of invasion and metastasis, tumor genetics, the immune microenvironment and the blood brain barrier. Novel targeted and immunotherapies are showing promise in brain metastases patients. We aim to bring together a panel of internationally recognized basic, translational, and clinical researchers in the field to discuss the latest advancements in the biology of brain metastases and the therapeutic implications of these advancements. The ultimate goal is to provide a forum for the exchange of ideas and importantly, to foster new collaborations to advance the field.


  • Evaluate and discuss the latest scientific advancements in brain metastases, including genomics, animal models, and the role of the immune microenvironment and blood brain barrier.
  • Develop strategies to incorporate emerging scientific advances to clinical trials and treatment paradigms.
  • Discuss the latest advanced imaging techniques for brain metastases and how they can be applied to clinical trials.
  • Evaluate the role of novel targeted therapies and immunotherapies in the management of brain metastases.


Friday, June 29

8:30  am        Registration & Breakfast                              

Welcoming Remarks
9:00 am          Priscilla Brastianos, MD
          Massachusetts General Hospital Cancer Center

                    Matthias Preusser, MD
              Medical University of Vienna

Advances in Animal Models for Brain Metastases and Leptomeningeal Disease
9:10 am          Adrienne Boire, MD, PhD
                       Memorial Sloan Kettering Cancer Center

 9:35 am         Patricia Steeg, PhD
                       National Cancer Institute
                       Center for Cancer Research

10:00 am       Frits Thorsen, PhD
                     University of Bergen

Tumor Microenvironment
10:25 am        Manuel Valiente, DVM, PhD
                       CNIO - Centro Nacional de Investigaciones Oncológicas 

10:50 am        Break 

11:05 am        Frank Winkler, MD
                       University of Heidelberg

11:30 am      Anna Berghoff, MD, PhD
            Medical University of Vienna

11:55 am       Josh Neman, PhD
University of Southern California

12:20 pm        Lunch

Tumor Genomics
1:15 pm          Scott Carter, PhD
                       Dana-Farber Cancer Institute

1:40 pm         Priscilla Brastianos, MD
                       Massachusetts General Hospital Cancer Center

2:05 pm          Christina Curtis, PhD, MSc
                      Stanford University School of Medicine

Oral Abstracts
2:30–5:30 pm  Moderator: Dan Cahill, MD, PhD
Massachusetts General Hospital

Poster Session & Reception @ Russell Museum
6:00–8:00 pm

Saturday, June 30
8:30 am          Registration & Breakfast

Novel Multi-Modality Translational and Clinical Trials
9:00 am         Erik Sulman, MD
                     MD Anderson Cancer Center

9:25 am         Caroline Chung, MD, MSc
                      MD Anderson Cancer Center

Advanced Imaging for Brain Metastases
9:50 am         
Elizabeth Gerstner, MD

                      Massachusetts General Hospital Cancer Center

Novel Clinical Trials in Immunotherapy and Targeted Therapy
10:15 am       Matthias Preusser, MD
                      Medical University of Vienna

10:50 am       Ryan Sullivan, MD
                      Massachusetts General Hospital Cancer Center

11:15 am       Break

11:25 am       Carey Anders, MD
                     UNC Lineberger Comprehensive Cancer Center

11:50 am       Priya Kumthekar, MD
                    Feinberg School of Medicine, Northwestern University

12:15 pm       Sara Tolaney, MD, MPH
                    Dana-Farber Cancer Institute

12:40 pm       Nancy Lin, MD
                    Dana-Farber Cancer Institute

1:05 pm         Justin Gainor, MD
Massachusetts General Hospital Cancer Center 

1:30 pm       Wrap up

1:45 pm         Program Adjourns